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  • Summary & Details

Molecular mechanisms for temperature detection through thermosensitive TRP channels

温度感受性TRP チャネルを介した温度感知のメカニズムと生理機能

Detailed Information

Category(J)PPT資料

Translation

Category(E)PPT slides
Author(J)1) 富永 真琴
Author(E)1) Makoto Tominaga
Affiliation(J)1) 生理学研究所/生命創成探究センター/総合研究大学院大学
Affiliation(E)1) NIPS/ExCELLS/SOKENDAI
Abstract(J)私たちは主に感覚神経もしくは皮膚表皮細胞に発現する温度感受性 TRPチャネルで環境温度を感知している。カプサイシン受容体TRPV1とメントール受容体TRPM8を発見した米国カリフォルニア大学サンフランシスコ校のDavid Juliusは2021年にノーベル生理学医学賞を受賞した。

Translation

Abstract(E)We detect ambient temperature through so called thermosensitive TRP channels expressed in sensory neurons or skin keratinocytes. David Julius awarded 2021 Nobel Prize in Physiology or Medicine for his discovery of temperature receptors such as capsaicin receptor TRPV1 and menthol receptor TRPM8 which are also activated by noxious heat and cold stimuli, respectively.

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